PD-L1 alternative splicing
PD-L1 is an immune checkpoint molecule which is upregulated in some tumors to evade the immune response. Generation of truncated and nonfunctional PD-L1 variants by modulation of alternative splicing presents a novel strategy for cancer treatments. PD-L1 alternative splicing was studied using minige...
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Nanyang Technological University
2022
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| Online Access: | https://hdl.handle.net/10356/156429 |
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sg-ntu-dr.10356-1564292023-12-11T15:33:27Z PD-L1 alternative splicing Zhen, Yashu Francesc Xavier Roca Castella School of Biological Sciences xroca@ntu.edu.sg Science::Biological sciences PD-L1 is an immune checkpoint molecule which is upregulated in some tumors to evade the immune response. Generation of truncated and nonfunctional PD-L1 variants by modulation of alternative splicing presents a novel strategy for cancer treatments. PD-L1 alternative splicing was studied using minigenes, to identify a splicing silencer inside Exon 4 exonic intron (exitron) which represses the splicing of this exitron. Besides, this splicing event seems to require the 5’ss splice site of Exon 4, and it is also negatively regulated by SRSF1 and the 3’ss splice site of Exon 6. Doctor of Philosophy 2022-04-13T12:39:35Z 2022-04-13T12:39:35Z 2021 Thesis-Doctor of Philosophy Zhen, Y. (2021). PD-L1 alternative splicing. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/156429 https://hdl.handle.net/10356/156429 en AcRF Tier 1 RG25/19(S) This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
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Science::Biological sciences Zhen, Yashu PD-L1 alternative splicing |
| description |
PD-L1 is an immune checkpoint molecule which is upregulated in some tumors to evade the immune response. Generation of truncated and nonfunctional PD-L1 variants by modulation of alternative splicing presents a novel strategy for cancer treatments. PD-L1 alternative splicing was studied using minigenes, to identify a splicing silencer inside Exon 4 exonic intron (exitron) which represses the splicing of this exitron. Besides, this splicing event seems to require the 5’ss splice site of Exon 4, and it is also negatively regulated by SRSF1 and the 3’ss splice site of Exon 6. |
| author2 |
Francesc Xavier Roca Castella |
| author_facet |
Francesc Xavier Roca Castella Zhen, Yashu |
| format |
Thesis-Doctor of Philosophy |
| author |
Zhen, Yashu |
| author_sort |
Zhen, Yashu |
| title |
PD-L1 alternative splicing |
| title_short |
PD-L1 alternative splicing |
| title_full |
PD-L1 alternative splicing |
| title_fullStr |
PD-L1 alternative splicing |
| title_full_unstemmed |
PD-L1 alternative splicing |
| title_sort |
pd-l1 alternative splicing |
| publisher |
Nanyang Technological University |
| publishDate |
2022 |
| url |
https://hdl.handle.net/10356/156429 |
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1787136739779805184 |