Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation

Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation

Hypoxic microenvironment is a hallmark of solid tumors, especially glioblastoma. The strong reliance of glioma-propagating cells (GPCs) on hypoxia-induced survival advantages is potentially exploitable for drug development. Methods: To identify key signaling pathways for hypoxia adaptation by patien...

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Bibliographic Details
Main Authors: Cheng, Hong Sheng, Marvalim, Charlie, Zhu, Pengcheng, Law, Daniel Cheng Lui, Low, Jeremy Zhi Yan, Chong, Yuk Kien, Ang, Beng Ti, Tang, Carol, Tan, Nguan Soon
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Medicine
Glioblastoma
Oxidative Stress
Online Access:https://hdl.handle.net/10356/153593
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/153593

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