Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation

• Main Authors: Cheng, Hong Sheng, Marvalim, Charlie, Zhu, Pengcheng, Law, Daniel Cheng Lui, Low, Jeremy Zhi Yan, Chong, Yuk Kien, Ang, Beng Ti, Tang, Carol, Tan, Nguan Soon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Glioblastoma; Oxidative Stress
• Online Access: https://hdl.handle.net/10356/153593
• Institution: Nanyang Technological University

Hypoxic microenvironment is a hallmark of solid tumors, especially glioblastoma. The strong reliance of glioma-propagating cells (GPCs) on hypoxia-induced survival advantages is potentially exploitable for drug development. Methods: To identify key signaling pathways for hypoxia adaptation by patien...