Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation

• Main Authors: Cheng, Hong Sheng, Marvalim, Charlie, Zhu, Pengcheng, Law, Daniel Cheng Lui, Low, Jeremy Zhi Yan, Chong, Yuk Kien, Ang, Beng Ti, Tang, Carol, Tan, Nguan Soon
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Medicine; Glioblastoma; Oxidative Stress
• 在線閱讀: https://hdl.handle.net/10356/153593
• 機構: Nanyang Technological University

Hypoxic microenvironment is a hallmark of solid tumors, especially glioblastoma. The strong reliance of glioma-propagating cells (GPCs) on hypoxia-induced survival advantages is potentially exploitable for drug development. Methods: To identify key signaling pathways for hypoxia adaptation by patien...