The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus
The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does no...
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sg-ntu-dr.10356-1536782024-04-23T03:03:13Z The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus Sorayah, Ria Moraski, Garret C. Barkan, Daniel Pethe, Kevin Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences Interdisciplinary Graduate School (IGS) Medicine, Health and Life Sciences Telacebec Clofazamine Mycobacterium abscessus The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does not potentiate the activity of clofazimine. Nanyang Technological University National Research Foundation (NRF) Submitted/Accepted version This work was supported in part by the Lee Kong Chian School of Medicine, Nanyang Technological University (Singapore), Start-Up Grant (K.P.) and the National Research Foundation (Singapore) under its Investigatorship Program (grant NRF-NRFI06-2020-0004). R.S. is supported by a scholarship from the NTU Institute for Health Technologies, Interdisciplinary Graduate Program, Nanyang Technological University. 2022-01-07T06:09:44Z 2022-01-07T06:09:44Z 2021 Journal Article Sorayah, R., Moraski, G. C., Barkan, D. & Pethe, K. (2021). The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus. Antimicrobial Agents and Chemotherapy, 65(12), e0096421-. https://dx.doi.org/10.1128/AAC.00964-21 0066-4804 https://hdl.handle.net/10356/153678 10.1128/AAC.00964-21 34543090 2-s2.0-85119367530 12 65 e0096421 en NRF-NRFI06-2020-0004 Antimicrobial Agents and Chemotherapy © 2021 American Society for Microbiology. All Rights Reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1128/AAC.00964-21. application/pdf |
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Nanyang Technological University |
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Medicine, Health and Life Sciences Telacebec Clofazamine Mycobacterium abscessus |
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Medicine, Health and Life Sciences Telacebec Clofazamine Mycobacterium abscessus Sorayah, Ria Moraski, Garret C. Barkan, Daniel Pethe, Kevin The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus |
| description |
The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does not potentiate the activity of clofazimine. |
| author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Sorayah, Ria Moraski, Garret C. Barkan, Daniel Pethe, Kevin |
| format |
Article |
| author |
Sorayah, Ria Moraski, Garret C. Barkan, Daniel Pethe, Kevin |
| author_sort |
Sorayah, Ria |
| title |
The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus |
| title_short |
The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus |
| title_full |
The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus |
| title_fullStr |
The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus |
| title_full_unstemmed |
The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus |
| title_sort |
qcrb inhibitors tb47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus |
| publishDate |
2022 |
| url |
https://hdl.handle.net/10356/153678 |
| _version_ |
1806059893798469632 |