The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus

• Main Authors: Sorayah, Ria, Moraski, Garret C., Barkan, Daniel, Pethe, Kevin
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Medicine, Health and Life Sciences; Telacebec; Clofazamine; Mycobacterium abscessus
• Online Access: https://hdl.handle.net/10356/153678
• Institution: Nanyang Technological University

The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does no...