Tracking oxidation-induced alterations in fibrin clot formation by NMR-based methods

• Main Authors: Lau, Wai-Hoe, White, Nathan J., Yeo, Tsin Wen, Gruen, Russell L., Pervushin, Konstantin
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Alpha-C Fragments; Magnetic-Resonance
• Online Access: https://hdl.handle.net/10356/153773
• Institution: Nanyang Technological University

Plasma fibrinogen is an important coagulation factor and susceptible to post-translational modification by oxidants. We have reported impairment of fibrin polymerization after exposure to hypochlorous acid (HOCl) and increased methionine oxidation of fibrinogen in severely injured trauma patients. M...