Nucleophilic amination of methoxy arenes promoted by a sodium hydride/iodide composite

• Main Authors: Kaga, Atsushi, Hayashi, Hirohito, Hakamata, Hiroyuki, Oi, Miku, Uchiyama, Masanobu, Takita, Ryo, Chiba, Shunsuke
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Amination; Nitrogen Heterocycles
• Online Access: https://hdl.handle.net/10356/154854
• Institution: Nanyang Technological University

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual conc...