FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression

• Main Authors: Puan, Kia Joo, San Luis, Boris, Nurhashikin Yusof, Kumar, Dilip, Andiappan, Anand Kumar, Lee, Wendy, Cajic, Samanta, Vuckovic, Dragana, Chan, Jing De, Döllner, Tobias, Hou, Han Wei, Jiang, Yunxuan, Tian, Chao, Rapp, Erdmann, Poidinger, Michael, Wang, De Yun, Soranzo, Nicole, Lee, Bernett, Rötzschke, Olaf
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Engineering::Mechanical engineering; Mast-Cells; T-Cells
• Online Access: https://hdl.handle.net/10356/154951
• Institution: Nanyang Technological University

Sialyl-Lewis x (sLex, CD15s) is a tetra-saccharide on the surface of leukocytes required for E-selectin-mediated rolling, a prerequisite for leukocytes to migrate out of the blood vessels. Here we show using flow cytometry that sLex expression on basophils and mast cell progenitors depends on fucosy...