Catalytic atroposelective synthesis of axially chiral benzonitriles via chirality control during bond dissociation and CN group formation

• Main Authors: Lv, Ya, Luo, Guoyong, Liu, Qian, Jin, Zhichao, Zhang, Xinglong, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Catalyst; Chemical Bonding
• Online Access: https://hdl.handle.net/10356/155057
• Institution: Nanyang Technological University

The applications of axially chiral benzonitriles and their derivatives remain mostly unexplored due to their synthetic difficulties. Here we disclose an unusual strategy for atroposelective access to benzonitriles via formation of the nitrile unit on biaryl scaffolds pre-installed with stereogenic a...