Regio-and stereoselective C(sp<sup>2</sup>)-H acylation of enamides with aldehydes : via transition-metal-free photoredox catalysis

A straightforward and efficient C(sp2)-H acylation of enamides with aldehydes via transition-metal-free photoredox catalysis is demonstrated. The transformation proceeded smoothly without resorting to expensive and potentially toxic iridium or ruthenium polypyridyl-based photocatalysts under mild co...

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Bibliographic Details
Main Authors: Zhao, Kai, Zhang, Xiao-Chen, Tao, Ji-Yu, Wu, Xian-Dan, Wu, Jia-Xu, Li, Wei-Ming, Zhu, Tong-Hao, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Online Access:https://hdl.handle.net/10356/155611
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Institution: Nanyang Technological University
Language: English
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Summary:A straightforward and efficient C(sp2)-H acylation of enamides with aldehydes via transition-metal-free photoredox catalysis is demonstrated. The transformation proceeded smoothly without resorting to expensive and potentially toxic iridium or ruthenium polypyridyl-based photocatalysts under mild conditions, furnishing a diverse range of synthetically crucial, geometrically defined β-acylated enamides in a stereoselective and regioselective manner. This journal is