Mutational analysis of mycobacterial F‑ATP synthase subunit δ leads to a potent δ enzyme inhibitor

• Main Authors: Harikishore, Amaravadhi, Saw, Wuan-Geok, Ragunathan, Priya, Litty, Dennnis, Dick, Thomas, Müller, Volker, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences::Biochemistry; Tuberculosis; Mycobacteria
• Online Access: https://hdl.handle.net/10356/155759
• Institution: Nanyang Technological University

While many bacteria are able to bypass the requirement for oxidative phosphorylation when grown on carbohydrates, Mycobacterium tuberculosis is unable to do so. Differences of amino acid composition and structural features of the mycobacterial F-ATP synthase (α3:β3:γ:δ:ε:a:b:b′:c9) compared to its p...