Chelating phosphine-N-heterocyclic carbene platinum complexes via catalytic asymmetric hydrophosphination and their cytotoxicity toward MKN74 and MCF7 cancer cell lines

• Main Authors: Seah, Jeffery Wee Kiong, Lee, Jeannie Xue Ting, Li, Yongxin, Pullarkat, Sumod A., Tan, Nguan Soon, Leung, Pak-Hing
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Chelating Phosphines; Cells
• Online Access: https://hdl.handle.net/10356/157005
• Institution: Nanyang Technological University

A series of activated vinyl azoles was hydrophosphinated in the presence of a chiral palladacycle catalyst under mild conditions to give enantioenriched phosphine azoles with moderate enantioselectivities and yields. The racemic phosphine azoles were transformed into eleven novel chelating phosphine...