Four-layered intramolecular parallel G-quadruplex with non-nucleotide loops: an ultra-stable self-folded DNA nano-scaffold

• Main Authors: Devi, Gitali, Winnerdy, Fernaldo Richtia, Ang, Jason Cheng Yu, Lim, Kah Wai, Phan, Anh Tuân
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Science::Biological sciences; Science::Physics; DNA; G-Quadruplex
• Online Access: https://hdl.handle.net/10356/158330
• Institution: Nanyang Technological University

A four-stranded scaffold of nucleic acids termed G-quadruplex (G4) has found growing applications in nano- and biotechnology. Propeller loops are a hallmark of the most stable intramolecular parallel-stranded G4s. To date, propeller loops have been observed to span only a maximum of three G-tetrad l...