Sensitivity of mycobacterium leprae to telacebec

The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis. The unprecedented potency of Telacebec against M. leprae wa...

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Main Authors:	Lahiri, Ramanuj, Adams, Linda B., Thomas, Sangeeta Susan, Pethe, Kevin
Other Authors:	Lee Kong Chian School of Medicine (LKCMedicine)
Format:	Article
Language:	English
Published:	2022
Subjects:	Science::Medicine Leprosy Telacebec
Online Access:	https://hdl.handle.net/10356/160139
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-160139
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spelling	sg-ntu-dr.10356-1601392023-03-05T16:52:19Z Sensitivity of mycobacterium leprae to telacebec Lahiri, Ramanuj Adams, Linda B. Thomas, Sangeeta Susan Pethe, Kevin Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Leprosy Telacebec The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis. The unprecedented potency of Telacebec against M. leprae warrants further validation in clinical trials. Nanyang Technological University National Research Foundation (NRF) Published version This work was supported in part by the Lee Kong Chian School of Medicine, Nanyang Technological University Start-Up Grant (K.P.), the National Research Foundation, Singapore, under its Investigatorship Programme (grant no. NRF-NRFI06-2020-0004), and the New York Community Trust Heiser Program (grant no. P18-000248). US National Institute of Allergy and Infectious Diseases funded the provision of viable M. leprae through an interagency agreement with Health Resources and Services Administration, Healthcare Systems Bureau, National Hansen’s Disease Program (no. AAI20009-001-00000). 2022-07-13T06:41:50Z 2022-07-13T06:41:50Z 2022 Journal Article Lahiri, R., Adams, L. B., Thomas, S. S. & Pethe, K. (2022). Sensitivity of mycobacterium leprae to telacebec. Emerging Infectious Diseases, 28(3), 749-751. https://dx.doi.org/10.3201/eid2803.210394 1080-6040 https://hdl.handle.net/10356/160139 10.3201/eid2803.210394 35202539 2-s2.0-85125256543 3 28 749 751 en NRF-NRFI06-2020-0004 Emerging Infectious Diseases 2022 Public domain. Published by the Centers for Disease Control and Prevention (CDC), a U.S. Government agency. This is an open-access article distributed under the terms of the Creative Commons Attribution License. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Science::Medicine Leprosy Telacebec
spellingShingle	Science::Medicine Leprosy Telacebec Lahiri, Ramanuj Adams, Linda B. Thomas, Sangeeta Susan Pethe, Kevin Sensitivity of mycobacterium leprae to telacebec
description	The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis. The unprecedented potency of Telacebec against M. leprae warrants further validation in clinical trials.
author2	Lee Kong Chian School of Medicine (LKCMedicine)
author_facet	Lee Kong Chian School of Medicine (LKCMedicine) Lahiri, Ramanuj Adams, Linda B. Thomas, Sangeeta Susan Pethe, Kevin
format	Article
author	Lahiri, Ramanuj Adams, Linda B. Thomas, Sangeeta Susan Pethe, Kevin
author_sort	Lahiri, Ramanuj
title	Sensitivity of mycobacterium leprae to telacebec
title_short	Sensitivity of mycobacterium leprae to telacebec
title_full	Sensitivity of mycobacterium leprae to telacebec
title_fullStr	Sensitivity of mycobacterium leprae to telacebec
title_full_unstemmed	Sensitivity of mycobacterium leprae to telacebec
title_sort	sensitivity of mycobacterium leprae to telacebec
publishDate	2022
url	https://hdl.handle.net/10356/160139
_version_	1759856457516318720

Sensitivity of mycobacterium leprae to telacebec

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