Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions

Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions

Reported herein is a practical method for macrolactam synthesis via a Rh(III)-catalyzed ring closing alkene-alkene cross-coupling reaction. The reaction proceeded via a Rh-catalyzed alkenyl sp2 C-H activation process, which allows access to macrocyclic molecules of different ring sizes. Macrolactams...

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Main Authors: Maraswami, Manikantha, Goh, Jeffrey, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Metathesis
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Online Access:https://hdl.handle.net/10356/160363
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1603632022-07-20T02:15:14Z Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions Maraswami, Manikantha Goh, Jeffrey Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry Metathesis Access Reported herein is a practical method for macrolactam synthesis via a Rh(III)-catalyzed ring closing alkene-alkene cross-coupling reaction. The reaction proceeded via a Rh-catalyzed alkenyl sp2 C-H activation process, which allows access to macrocyclic molecules of different ring sizes. Macrolactams containing a conjugated diene framework could be easily prepared in high chemoselectivities and Z,E stereoselectivities. Ministry of Education (MOE) Nanyang Technological University The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (No. 21702108), the Natural Science Foundation of Jiangsu Province, China (No. BK20160977), the Six Talent Peaks Project in Jiangsu Province (No. YY-033), Tier 1 grant M4012045.110 (No. RG12/18-S) from the Ministry of Education of Singapore and Distinguished University Professor grant, Nanyang Technological University, Singapore. 2022-07-20T02:15:14Z 2022-07-20T02:15:14Z 2020 Journal Article Maraswami, M., Goh, J. & Loh, T. (2020). Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions. Organic Letters, 22(24), 9724-9728. https://dx.doi.org/10.1021/acs.orglett.0c03801 1523-7060 https://hdl.handle.net/10356/160363 10.1021/acs.orglett.0c03801 33258611 2-s2.0-85097757281 24 22 9724 9728 en RG12/18-S Organic Letters © 2020 American Chemical Society. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Metathesis
Access
spellingShingle Science::Chemistry
Metathesis
Access
Maraswami, Manikantha
Goh, Jeffrey
Loh, Teck-Peng
Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions
description Reported herein is a practical method for macrolactam synthesis via a Rh(III)-catalyzed ring closing alkene-alkene cross-coupling reaction. The reaction proceeded via a Rh-catalyzed alkenyl sp2 C-H activation process, which allows access to macrocyclic molecules of different ring sizes. Macrolactams containing a conjugated diene framework could be easily prepared in high chemoselectivities and Z,E stereoselectivities.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Maraswami, Manikantha
Goh, Jeffrey
Loh, Teck-Peng
format Article
author Maraswami, Manikantha
Goh, Jeffrey
Loh, Teck-Peng
author_sort Maraswami, Manikantha
title Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions
title_short Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions
title_full Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions
title_fullStr Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions
title_full_unstemmed Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions
title_sort macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions
publishDate 2022
url https://hdl.handle.net/10356/160363
_version_ 1739837390907768832

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