Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions

• Main Authors: Maraswami, Manikantha, Goh, Jeffrey, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Metathesis; Access
• Online Access: https://hdl.handle.net/10356/160363
• Institution: Nanyang Technological University

Reported herein is a practical method for macrolactam synthesis via a Rh(III)-catalyzed ring closing alkene-alkene cross-coupling reaction. The reaction proceeded via a Rh-catalyzed alkenyl sp2 C-H activation process, which allows access to macrocyclic molecules of different ring sizes. Macrolactams...