The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling
The steroidal lactone withaferin A (WFA) is a dietary phytochemical, derived from Withania somnifera. It exhibits a wide range of biological properties, including immunomodulatory, anti-inflammatory, antistress, and anticancer activities. Here we investigated the effect of WFA on T-cell motility, wh...
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Main Authors: | Mobashar Hussain Urf Turabe Fazil, Chirumamilla, Chandra Sekhar, Perez-Novo, Claudina, Wong, Brandon Han Siang, Kumar, Sunil, Sze, Siu Kwan, Berghe, Wim Vanden, Verma, Navin Kumar |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2022
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/161091 |
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Institution: | Nanyang Technological University |
Language: | English |
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