Interception of enamine intermediates in reductive functionalization of lactams by sodium hydride: synthesis of 2-cyano-3-iodo piperidines and pyrrolidines

• المؤلفون الرئيسيون: Chen, Jiahua, Lim, Jun Wei, Chiba, Shunsuke
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Chemistry; Sodium Hydride; Lactams
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/161610

Facile conversion of 2-piperidones and 2-pyrrolidones into 2-cyano-3-iodo piperidines or pyrrolidines has been accomplished by the sequence of 1) controlled hydride reduction of lactams using sodium hydride (NaH) in the presence of sodium iodide (NaI); 2) silylation of anionic hemiaminal intermediat...