The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis

• Main Authors: Yap, Wei Sheng, Shyu Jr., Peter, Gaspar, Maria Laura, Jesch, Stephen A., Marvalim, Charlie, Prinz, William A., Henry, Susan A., Thibault, Guillaume
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Endoplasmic Reticulum-Associated Degradation; Lipid Droplet; Proteostasis; Phospholipid Metabolism; Unfolded Protein Response
• Online Access: https://hdl.handle.net/10356/161980
• Institution: Nanyang Technological University

Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage-inducing transmembrane (FIT; also known as FITM) family induces LD formation. Here, we establish a model system to study the role of the Saccharomyces cerevisiae FIT homologues (ScFIT), SCS3 and YFT...