Asparaginyl endopeptidase-mediated protein C-terminal hydrazinolysis for the synthesis of bioconjugates

Asparaginyl endopeptidase-mediated protein C-terminal hydrazinolysis for the synthesis of bioconjugates

Asparaginyl endopeptidases (AEPs) are cysteinyl enzymes naturally catalyzing the hydrolysis and transpeptidation reactions at Asx-Xaa bonds. These reactions go by a common acyl-enzyme thioester intermediate, which is either attacked by water (for a protease-AEP) or by a peptidic amine nucleophile (f...

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Bibliographic Details
Main Authors: Zhang, Dingpeng, Wang, Zhen, Hu, Side, Chan, Ning-Yu, Liew, Heng Tai, Lescar, Julien, Tam, James P., Liu, Chuan-Fa
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Asparaginyl
Bioconjugates
Online Access:https://hdl.handle.net/10356/162124
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/162124

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