Anti-Mycobacterium abscessus activity of tuberculosis F-ATP synthase inhibitor GaMF1

Anti-Mycobacterium abscessus activity of tuberculosis F-ATP synthase inhibitor GaMF1

New drug targets and molecules with bactericidal activity are needed against the respiratory mycobacterial pathogen Mycobacterium abscessus (Mab). Employing a lead repurposing strategy, the anti-tuberculosis compound GaMF1 was tested against Mab. Whole cell- and ATP synthesis assays demonstrated tha...

Full description

Saved in:
Bibliographic Details
Main Authors: Ragunathan, Priya, Dick, Thomas, Grüber, Gerhard
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry::Biochemistry
Mycobacterium Abscessus
Nontuberculous Mycobacteria
Bioenergetics
F-ATP Synthase
γ Subunit Inhibitor
Multi Drug Resistance
Online Access:https://hdl.handle.net/10356/163132
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
Description
Summary:New drug targets and molecules with bactericidal activity are needed against the respiratory mycobacterial pathogen Mycobacterium abscessus (Mab). Employing a lead repurposing strategy, the anti-tuberculosis compound GaMF1 was tested against Mab. Whole cell- and ATP synthesis assays demonstrated that GaMF1 inhibits growth and kills Mab by targeting the F-ATP synthase. GaMF1’s anti-Mab activity increased in combination with clofazimine, rifabutin or amikacin The study expands the repertoire of anti-Mab compounds targeting oxidative phosphorylation.

Similar Items