Anti-Mycobacterium abscessus activity of tuberculosis F-ATP synthase inhibitor GaMF1

• Main Authors: Ragunathan, Priya, Dick, Thomas, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry::Biochemistry; Mycobacterium Abscessus; Nontuberculous Mycobacteria; Bioenergetics; F-ATP Synthase; γ Subunit Inhibitor; Multi Drug Resistance
• Online Access: https://hdl.handle.net/10356/163132
• Institution: Nanyang Technological University

New drug targets and molecules with bactericidal activity are needed against the respiratory mycobacterial pathogen Mycobacterium abscessus (Mab). Employing a lead repurposing strategy, the anti-tuberculosis compound GaMF1 was tested against Mab. Whole cell- and ATP synthesis assays demonstrated that GaMF1 inhibits growth and kills Mab by targeting the F-ATP synthase. GaMF1’s anti-Mab activity increased in combination with clofazimine, rifabutin or amikacin The study expands the repertoire of anti-Mab compounds targeting oxidative phosphorylation.