Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy

Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy

The presence of apoptosis inhibition proteins renders the cancer cells resistant to apoptosis, severely compromising the antitumor efficacy of sonodynamic therapy (SDT). Here, an intelligent anticancer nanoplatform based on an Aza-boron-dipyrromethene dye (denoted as Aza-BDY) is elaborately establis...

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Bibliographic Details
Main Authors: You, Changwen, Li, Xingguang, Wang, Dongqiong, Chen, Hongzhong, Liang, Lei, Chen, Yu, Zhao, Yanli, Xiang, Huijing
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Cysteine Starvation
Ferroptosis
Online Access:https://hdl.handle.net/10356/163323
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Institution: Nanyang Technological University
Language: English
Description
Summary:The presence of apoptosis inhibition proteins renders the cancer cells resistant to apoptosis, severely compromising the antitumor efficacy of sonodynamic therapy (SDT). Here, an intelligent anticancer nanoplatform based on an Aza-boron-dipyrromethene dye (denoted as Aza-BDY) is elaborately established for ferroptosis augmented SDT through cysteine (Cys) starvation. After endocytosis by tumor cells, Aza-BDY serves as both a ferroptosis inducing agent and a sonosensitizer for tumor treatment. The specific Cys response facilitates the disruption of redox homeostasis and initiation of cellular ferroptosis. Meanwhile, the released sonosensitizer causes efficient SDT and augments ferroptosis under ultrasound irradiation. Detailed in vitro and in vivo investigations demonstrate that the synergistic effect of Cys depletion and singlet oxygen (1 O2 ) generation significantly induces cancer-cell death and suppresses tumor proliferation with a high inhibition rate of 97.5 %.

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