Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy

• Main Authors: You, Changwen, Li, Xingguang, Wang, Dongqiong, Chen, Hongzhong, Liang, Lei, Chen, Yu, Zhao, Yanli, Xiang, Huijing
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Cysteine Starvation; Ferroptosis
• Online Access: https://hdl.handle.net/10356/163323
• Institution: Nanyang Technological University

The presence of apoptosis inhibition proteins renders the cancer cells resistant to apoptosis, severely compromising the antitumor efficacy of sonodynamic therapy (SDT). Here, an intelligent anticancer nanoplatform based on an Aza-boron-dipyrromethene dye (denoted as Aza-BDY) is elaborately establis...