Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents

• Main Authors: Kim, Hyung Jun, Li, Yingying, Zimmermann, Michael, Lee, Yunmi, Lim, Hui Wen, Tan, Alvin Swee Leong, Choi, Inhee, Ko, Yoonae, Lee, Sangchul, Seo, Jeong Jea, Seo, Mooyoung, Jeon, Hee Kyoung, Cechetto, Jonathan, Yam, Joey Kuok Hoong, Yang, Liang, Sauer, Uwe, Jang, Soojin, Pethe, Kevin
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences::Biochemistry; Vitamin B1; Oxythiamine; Antimetabolite; Antibacterial; Fluorouracil; Auranofin; Synthetic Lethal Interactions; Antibacterial Screening; ESKAPE Pathogens
• Online Access: https://hdl.handle.net/10356/163407
• Institution: Nanyang Technological University

New therapeutic concepts are critically needed for carbapenem-resistant Pseudomonas aeruginosa, an opportunistic pathogen particularly recalcitrant to antibiotics. The screening of around 230,000 small molecules yielded a very low hit rate of 0.002% after triaging for known antibiotics. The only nov...