Skin models for cutaneous melioidosis reveal Burkholderia infection dynamics at wound's edge with inflammasome activation, keratinocyte extrusion and epidermal detachment

• Main Authors: Ku, Joanne Wei Kay, Marsh, Supatra Tharinee, Nai, Mui Hoon, Robinson, Kim Samirah, Teo, Daniel Eng Thiam, Zhong, Franklin Lei, Brown, Katherine A., Lim, Thiam Chye, Lim, Chwee Teck, Gan, Yunn-Hwen
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Burkholderia; Inflammasome
• Online Access: https://hdl.handle.net/10356/164847
• Institution: Nanyang Technological University

Melioidosis is a serious infectious disease endemic in Southeast Asia, Northern Australia and has been increasingly reported in other tropical and subtropical regions in the world. Percutaneous inoculation through cuts and wounds on the skin is one of the major modes of natural transmission. Despite...