The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression

• Main Authors: Fougeray, Tiffany, Polizzi, Arnaud, Régnier, Marion, Fougerat, Anne, Ellero-Simatos, Sandrine, Lippi, Yannick, Smati, Sarra, Lasserre, Frédéric, Tramunt, Blandine, Huillet, Marine, Dopavogui, Léonie, Salvi, Juliette, Nédélec, Emmanuelle, Gigot, Vincent, Smith, Lorraine, Naylies, Claire, Sommer, Caroline, Haas, Joel T., Wahli, Walter, Duez, Hélène, Gourdy, Pierre, Gamet-Payrastre, Laurence, Benani, Alexandre, Burnol, Anne-Françoise, Loiseau, Nicolas, Postic, Catherine, Montagner, Alexandra, Guillou, Hervé
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Insulin Receptor; Circadian
• Online Access: https://hdl.handle.net/10356/164881
• Institution: Nanyang Technological University

Liver physiology is circadian and sensitive to feeding and insulin. Food intake regulates insulin secretion and is a dominant signal for the liver clock. However, how much insulin contributes to the effect of feeding on the liver clock and rhythmic gene expression remains to be investigated. Insulin...