Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency

• Main Authors: Ai, Zhipeng, Xiang, Xinyu, Xiang, Yangquan, Szczerbinska, Iwona, Qian, Yuli, Xu, Xiao, Ma, Chenyang, Su, Yaqi, Gao, Bing, Shen, Hao, Muhammad Nadzim Bin Ramli, Chen, Di, Liu, Yue, Hao, Jia-Jie, Ng, Huck Hui, Zhang, Dan, Chan, Yun-Shen, Liu, Wanlu, Liang, Hongqing
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Cell Potency; Naive and Primed Pluripotency
• Online Access: https://hdl.handle.net/10356/164884
• Institution: Nanyang Technological University

Endogenous retroviruses (ERVs) have been reported to participate in pre-implantation development of mammalian embryos. In early human embryogenesis, different ERV sub-families are activated in a highly stage-specific manner. How the specificity of ERV activation is achieved remains largely unknown....