Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum

Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum

Resistance of the human malaria parasites, Plasmodium falciparum, to artemisinins is now fully established in Southeast Asia and is gradually emerging in Sub-Saharan Africa. Although nonsynonymous SNPs in the pfk13 Kelch-repeat propeller (KREP) domain are clearly associated with artemisinin resistan...

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Bibliographic Details
Main Authors: Kucharski, Michal, Wirjanata, Grennady, Nayak, Sourav, Boentoro, Josephine, Dziekan, Jerzy Michal, Assisi, Christina, van der Pluijm, Rob W., Miotto, Olivo, Mok, Sachel, Dondorp, Arjen M., Bozdech, Zbynek
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2023
Subjects:
Science::Biological sciences
Antiparasitic Agent
Plasmodium Falciparum
Online Access:https://hdl.handle.net/10356/165601
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/165601

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