The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi

• Main Authors: Chan, Louisa L. Y., Anderson, Danielle E., Cheng, Hong Sheng, Ivan, Fransiskus Xaverius, Chen, Si, Kang, Adrian E. Z., Foo, Randy, Gamage, Akshamal M., Tiew, Pei Yee, Koh, Mariko Siyue, Lee, Ken Cheah Hooi, Nichol, Kristy, Pathinayake, Prabuddha S., Chan, Yik Lung, Yeo, Tsin Wen, Oliver, Brian G., Wark, Peter A. B., Liu, Linbo, Tan, Nguan Soon, Wang, Lin-Fa, Chotirmall, Sanjay Haresh
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Bronchi; COVID-19
• Online Access: https://hdl.handle.net/10356/168660
• Institution: Nanyang Technological University

Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and infective exacerbations, however, in-vitro model systems for the study of host-pathogen interaction at the individual level are lacking. Here, we describe the establishment of nasopharyngeal and bronchial organoi...