Engineering the Phenylpropanoid pathway in Rhodosporidium toruloides for naringenin production from tyrosine by leveraging on its native PAL gene

• Main Authors: Lee, Jaslyn Jie Lin, Ng, Kuan Rei, Liang, Jiaqi, Cui, Xi, Li, Aaron, Chen, Wei Ning
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Flavonoids; Naringenin
• Online Access: https://hdl.handle.net/10356/169058
• Institution: Nanyang Technological University

Flavonoids are valued for their beneficial properties. This was a proof-of-concept study to show that the PAL gene in Rhodosporidium toruloides (R. toruloides) could be harnessed and only two genes 4CL and CHS needed to be inserted to create the naringenin producing strain, CBS-N. The growth of CBS-...