Nickel-catalyzed enantioselective reductive arylation and heteroarylation of aldimines via an elementary 1,4-addition

• Main Authors: Zhang, Luoqiang, Wang, Xiuhua, Pu, Maoping, Chen, Caiyou, Yang, Peng, Wu, Yun-Dong, Chi, Robin Yonggui, Zhou, Steve Jianrong
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Density Functional Theory; Aldimines
• Online Access: https://hdl.handle.net/10356/170562
• Institution: Nanyang Technological University

Nickel catalysts of chiral pyrox ligands promoted enantioselective reductive arylation and heteroarylation of aldimines, using directly (hetero)aryl halides and sulfonates. The catalytic arylation can also be conducted with crude aldimines generated from condensation of aldehydes and azaaryl amines....