Multiplexed RNA profiling by regenerative catalysis enables blood-based subtyping of brain tumors

• Main Authors: Zhang, Yan, Wong, Chi Yan, Lim, Carine Z. J., Chen, Qingchang, Yu, Zhonglang, Natalia, Auginia, Wang, Zhigang, Pang, Qing You, Lim, See Wee, Loh, Tze Ping, Ang, Beng Ti, Tang, Carol, Shao, Huilin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Science::Medicine; Blood Sampling; Brain Tumor
• Online Access: https://hdl.handle.net/10356/171539
• Institution: Nanyang Technological University

Current technologies to subtype glioblastoma (GBM), the most lethal brain tumor, require highly invasive brain biopsies. Here, we develop a dedicated analytical platform to achieve direct and multiplexed profiling of circulating RNAs in extracellular vesicles for blood-based GBM characterization. Th...