A bacterial quorum sensing regulated protease inhibits host immune responses by cleaving death domains of innate immune adaptors

• Main Authors: Duan, Xiangke, Boo, Zhao Zhi, Chua, Song Lin, Chong, Kelvin Han Chung, Long, Ziqi, Yang, Renliang, Zhou, Yachun, Janela, Baptiste, Chotirmall, Sanjay Haresh, Ginhoux, Florent, Hu, Qinghua, Wu, Bin, Yang, Liang
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Science::Medicine; Host-Microbe Interaction; Pseudomonas Aeruginosa
• Online Access: https://hdl.handle.net/10356/172985
• Institution: Nanyang Technological University

Innate immune adaptor proteins are critical components of the innate immune system that propagate pro-inflammatory responses from their upstream receptors, and lead to pathogen clearance from the host. Bacterial pathogens have developed strategies to survive inside host cells without triggering the...