Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy

• Main Authors: So, Wing Yan, Liao, Yilie, Liu, Wai Nam, Rutter, Guy A., Han, Weiping
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Beta cells; Diabetes
• Online Access: https://hdl.handle.net/10356/173758
• Institution: Nanyang Technological University

Loss of pancreatic beta cells is the central feature of all forms of diabetes. Current therapies fail to halt the declined beta cell mass. Thus, strategies to preserve beta cells are imperatively needed. In this study, we identified paired box 6 (PAX6) as a critical regulator of beta cell survival....