Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy

• المؤلفون الرئيسيون: So, Wing Yan, Liao, Yilie, Liu, Wai Nam, Rutter, Guy A., Han, Weiping
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Medicine, Health and Life Sciences; Beta cells; Diabetes
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/173758
• المؤسسة: Nanyang Technological University

Loss of pancreatic beta cells is the central feature of all forms of diabetes. Current therapies fail to halt the declined beta cell mass. Thus, strategies to preserve beta cells are imperatively needed. In this study, we identified paired box 6 (PAX6) as a critical regulator of beta cell survival....