A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria
The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. We previously reported that polyimidazolium (PIM) compounds exhibited signi...
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sg-ntu-dr.10356-1742182024-03-22T15:31:52Z A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria Chen, Yahua Yong, Melvin Li, Ming Si, Zhangyong Koh, Chong Hui Lau, Pearlyn Chang, Yi Wei Teo, Jeanette Chan-Park, Mary B. Gan, Yunn-Hwen School of Chemistry, Chemical Engineering and Biotechnology Chemistry Antibiotic agent Drug resistance The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. We previously reported that polyimidazolium (PIM) compounds exhibited significant antimicrobial activity and minimal mammalian cytotoxicity. However, their mechanism of action is relatively unknown. We examined the efficacy and mechanism of action of a hydrophilic PIM (PIM5) against colistin- and meropenem-resistant clinical isolates. Ministry of Education (MOE) Published version This research is supported by the Ministry of Education, Singapore, under its MOE AcRF Tier 3 Award of MOE2018-T3-1-003. Melvin Yong acknowledges the support of the Ministry of Education, Singapore, under its MOE AcRF Tier 3 Award (MOE2018-T3-1-003) for the support of an MOE PhD scholarship. Chong Hui Koh acknowledges the support of an NTU PhD scholarship. 2024-03-21T05:37:54Z 2024-03-21T05:37:54Z 2023 Journal Article Chen, Y., Yong, M., Li, M., Si, Z., Koh, C. H., Lau, P., Chang, Y. W., Teo, J., Chan-Park, M. B. & Gan, Y. (2023). A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria. Journal of Antimicrobial Chemotherapy, 78(10), 2581-2590. https://dx.doi.org/10.1093/jac/dkad274 0305-7453 https://hdl.handle.net/10356/174218 10.1093/jac/dkad274 37671807 2-s2.0-85174080662 10 78 2581 2590 en MOE2018-T3-1-003 Journal of Antimicrobial Chemotherapy © 2023 The Author(s). Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https:// creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com application/pdf |
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Nanyang Technological University |
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Asia |
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Singapore Singapore |
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| language |
English |
| topic |
Chemistry Antibiotic agent Drug resistance |
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Chemistry Antibiotic agent Drug resistance Chen, Yahua Yong, Melvin Li, Ming Si, Zhangyong Koh, Chong Hui Lau, Pearlyn Chang, Yi Wei Teo, Jeanette Chan-Park, Mary B. Gan, Yunn-Hwen A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria |
| description |
The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. We previously reported that polyimidazolium (PIM) compounds exhibited significant antimicrobial activity and minimal mammalian cytotoxicity. However, their mechanism of action is relatively unknown. We examined the efficacy and mechanism of action of a hydrophilic PIM (PIM5) against colistin- and meropenem-resistant clinical isolates. |
| author2 |
School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet |
School of Chemistry, Chemical Engineering and Biotechnology Chen, Yahua Yong, Melvin Li, Ming Si, Zhangyong Koh, Chong Hui Lau, Pearlyn Chang, Yi Wei Teo, Jeanette Chan-Park, Mary B. Gan, Yunn-Hwen |
| format |
Article |
| author |
Chen, Yahua Yong, Melvin Li, Ming Si, Zhangyong Koh, Chong Hui Lau, Pearlyn Chang, Yi Wei Teo, Jeanette Chan-Park, Mary B. Gan, Yunn-Hwen |
| author_sort |
Chen, Yahua |
| title |
A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria |
| title_short |
A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria |
| title_full |
A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria |
| title_fullStr |
A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria |
| title_full_unstemmed |
A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria |
| title_sort |
hydrophilic polyimidazolium antibiotic targeting the membranes of gram-negative bacteria |
| publishDate |
2024 |
| url |
https://hdl.handle.net/10356/174218 |
| _version_ |
1794549462252650496 |