Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid

• Main Authors: Wei, Wenchao, Wong, Chi Chun, Jia, Zhongjun, Liu, Weixin, Liu, Changan, Ji, Fenfen, Pan, Yasi, Wang, Feixue, Wang, Guoping, Zhao, Liuyang, Chu, Eagle S. H., Zhang, Xiang, Sung, Joseph Jao Yiu, Yu, Jun
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Insulin; Pentadecanoic acid
• Online Access: https://hdl.handle.net/10356/174263
• Institution: Nanyang Technological University

Non-alcoholic steatohepatitis (NASH) is the severe form of non-alcoholic fatty liver disease, and is characterized by liver inflammation and fat accumulation. Dietary interventions, such as fibre, have been shown to alleviate this metabolic disorder in mice via the gut microbiota. Here, we investiga...