Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress
The hippocampal CA2 region has received greater attention in recent years due to its fundamental role in social memory and hippocampus-dependent memory processing. Unlike entorhinal cortical inputs, the Schaffer collateral inputs to CA2 do not support activity-dependent long-term potentiation (LTP),...
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sg-ntu-dr.10356-1745572024-04-07T15:41:19Z Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress Raghuraman, Radha Navakkode, Sheeja Sajikumar, Sreedharan Lee Kong Chian School of Medicine (LKCMedicine) Medicine, Health and Life Sciences Hippocampus Juvenile stress The hippocampal CA2 region has received greater attention in recent years due to its fundamental role in social memory and hippocampus-dependent memory processing. Unlike entorhinal cortical inputs, the Schaffer collateral inputs to CA2 do not support activity-dependent long-term potentiation (LTP), which serves as the basis for long-term memories. This LTP-resistant zone also expresses genes that restrict plasticity. With the aim of exploring social interaction and sociability in rats that were subjected to juvenile stress, we addressed questions about how the neural circuitry is altered and its effects on social behavior. Although there was induction of LTP in both Schaffer collateral and entorhinal cortical pathways in juvenile-stressed rats, LTP declined in both pathways after 2-3 h. Moreover, exogenous bath application of substance P, a neuropeptide that resulted in slow onset long-lasting potentiation in control animals while it failed to induce LTP in juvenile-stressed rats. Our study reveals that juvenile-stressed rats show behavioral and cellular abnormalities with a long-lasting impact in adulthood. Published version This work was supported by Ministry of Health (MOH‐000641‐00), Ministry of Education Academic Research Fund Tier 3 (MOE2017‐T3‐1‐002), NUHS Seed Fund (NUHSRO/2020/145/RO5+6/Seed‐Sep/05) and NUSMED‐FOS Joint Research Programme (NUHSRO/2018/075/NUSMed‐FoS/01) to Sreedharan Sajikumar. Radha Raghuraman is supported by NUS Research Scholarship, National University of Singapore. 2024-04-02T06:15:29Z 2024-04-02T06:15:29Z 2023 Journal Article Raghuraman, R., Navakkode, S. & Sajikumar, S. (2023). Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress. Hippocampus, 33(6), 745-758. https://dx.doi.org/10.1002/hipo.23531 1050-9631 https://hdl.handle.net/10356/174557 10.1002/hipo.23531 36965045 2-s2.0-85150963545 6 33 745 758 en Hippocampus © 2023 The Authors. Hippocampus published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. application/pdf |
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Medicine, Health and Life Sciences Hippocampus Juvenile stress Raghuraman, Radha Navakkode, Sheeja Sajikumar, Sreedharan Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress |
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The hippocampal CA2 region has received greater attention in recent years due to its fundamental role in social memory and hippocampus-dependent memory processing. Unlike entorhinal cortical inputs, the Schaffer collateral inputs to CA2 do not support activity-dependent long-term potentiation (LTP), which serves as the basis for long-term memories. This LTP-resistant zone also expresses genes that restrict plasticity. With the aim of exploring social interaction and sociability in rats that were subjected to juvenile stress, we addressed questions about how the neural circuitry is altered and its effects on social behavior. Although there was induction of LTP in both Schaffer collateral and entorhinal cortical pathways in juvenile-stressed rats, LTP declined in both pathways after 2-3 h. Moreover, exogenous bath application of substance P, a neuropeptide that resulted in slow onset long-lasting potentiation in control animals while it failed to induce LTP in juvenile-stressed rats. Our study reveals that juvenile-stressed rats show behavioral and cellular abnormalities with a long-lasting impact in adulthood. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Raghuraman, Radha Navakkode, Sheeja Sajikumar, Sreedharan |
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Article |
author |
Raghuraman, Radha Navakkode, Sheeja Sajikumar, Sreedharan |
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Raghuraman, Radha |
title |
Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress |
title_short |
Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress |
title_full |
Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress |
title_fullStr |
Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress |
title_full_unstemmed |
Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress |
title_sort |
alteration of hippocampal ca2 plasticity and social memory in adult rats impacted by juvenile stress |
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2024 |
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https://hdl.handle.net/10356/174557 |
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1814047147739316224 |