Recombinant perlecan domain V covalently immobilized on silk biomaterials via plasma immersion ion implantation supports the formation of functional endothelium

• Main Authors: Lau, Kieran, Fu, Lu, Zhang, Anyu, Akhavan, Behnam, Whitelock, John, Bilek, Marcela M., Lord, Megan S., Rnjak-Kovacina, Jelena
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Engineering; Biofunctionalization; Endothelium
• Online Access: https://hdl.handle.net/10356/174575
• Institution: Nanyang Technological University

Strategies to promote rapid formation of functional endothelium are required to maintain blood fluidity and regulate smooth muscle cell proliferation in synthetic vascular conduits. In this work, we explored the biofunctionalization of silk biomaterials with recombinantly expressed domain V of human...