The shelterin component TRF2 mediates columnar stacking of human telomeric chromatin

• Main Authors: Wong, Sook Yi, Soman, Aghil, Korolev, Nikolay, Surya, Wahyu, Chen, Qinming, Shum, Wayne, van Noort, John, Nordenskiöld, Lars
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Chromatin structure; Electron microscopy
• Online Access: https://hdl.handle.net/10356/174944
• Institution: Nanyang Technological University

Telomere repeat binding factor 2 (TRF2) is an essential component of the telomeres and also plays an important role in a number of other non-telomeric processes. Detailed knowledge of the binding and interaction of TRF2 with telomeric nucleosomes is limited. Here, we study the binding of TRF2 to in...