Synthesis of peptide antibiotics for Mycobacterium tuberculosis

• Main Author: Lin, Hong Xuan
• Other Authors: Roderick Wayland Bates
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2024
• Subjects: Chemistry; Medicine, Health and Life Sciences; Tuberculosis; Antibiotics; Antimicrobial resistance; Peptides; Antimicrobial peptides; ATP synthase inhibitor
• Online Access: https://hdl.handle.net/10356/175109
• Institution: Nanyang Technological University

Many drug candidates against TB fail in an early stage during primary screening. While they were discovered to be effective enzyme inhibitors, this did not always translate to effective inhibitors of bacterial growth. The primary reason for this is that the thick, hydrophobic cell wall of M. tubercu...