14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway

• Main Authors: Mukherjee, Soumita, Roy, Somesh, Mukherjee, Shruti, Harikishore, Amaravadhi, Bhunia, Anirban, Mandal, Atin K.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; CRAF kinase; Phosphodiesterase
• Online Access: https://hdl.handle.net/10356/178406
• Institution: Nanyang Technological University

The cAMP/PKA and mitogen-activated protein kinase (MAPK) signaling cascade control many cellular processes and are highly regulated for optimal cellular responses upon external stimuli. Phosphodiesterase 8A (PDE8A) is an important regulator that inhibits signaling via cAMP-dependent PKA by hydrolyzi...