14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway

• Main Authors: Mukherjee, Soumita, Roy, Somesh, Mukherjee, Shruti, Harikishore, Amaravadhi, Bhunia, Anirban, Mandal, Atin K.
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2024
• 主題: Medicine, Health and Life Sciences; CRAF kinase; Phosphodiesterase
• 在線閱讀: https://hdl.handle.net/10356/178406

The cAMP/PKA and mitogen-activated protein kinase (MAPK) signaling cascade control many cellular processes and are highly regulated for optimal cellular responses upon external stimuli. Phosphodiesterase 8A (PDE8A) is an important regulator that inhibits signaling via cAMP-dependent PKA by hydrolyzi...