Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum

• Main Authors: Song, Yutong, Zhao, Zhihao, Xu, Linyu, Huang, Peiyuan, Gao, Jiayang, Li, Jingxuan, Wang, Xuejie, Zhou, Yiren, Wang, Jinhui, Zhao, Wenting, Wang, Likun, Zheng, Chaogu, Gao, Bo, Jiang, Liwen, Liu, Kai, Guo, Yusong, Yao, Xiaoqiang, Duan, Liting
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; ER mechanostimulator; Optical dimerizer
• Online Access: https://hdl.handle.net/10356/180031
• Institution: Nanyang Technological University

The ability of cells to perceive and respond to mechanical cues is essential for numerous biological activities. Emerging evidence indicates important contributions of organelles to cellular mechanosensitivity and mechanotransduction. However, whether and how the endoplasmic reticulum (ER) senses an...