Computational analysis of β cell Ca2+ dynamics in situ

• Main Author: Yong, Fiona Su Wern
• Other Authors: Yusuf Ali
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2024
• Subjects: Medicine, Health and Life Sciences; Diabetes; Type-2 diabetes; Islet; Beta cell; Insulin; Signal binarisation; Lightsheet imaging; Multivariate autoregressive modelling; In-vivo imaging; Beta hub cells; Computational analysis
• Online Access: https://hdl.handle.net/10356/180358
• Institution: Nanyang Technological University

β hubs are a distinct subpopulation of pancreatic β cells arising from intra-islet β cell heterogeneity. Subject to the challenges of data collection in vivo in the living animal after engraftment of islets into the anterior eye chamber, mouse β hubs seem to be in a transient state when it comes to...