The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular quiescence/senescence and drug resilience

• Main Authors: Tripathi, Jaishree, Stoklasa, Michal, Nayak, Sourav, Low, Kay En, Lee, Erica Qian Hui, Tien, Quang Huy Duong, Rénia, Laurent, Malleret, Benoit, Bozdech, Zbynek
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Plasmodium falciparum; Artemisinin
• Online Access: https://hdl.handle.net/10356/180392
• Institution: Nanyang Technological University

Recrudescent infections with the human malaria parasite, Plasmodium falciparum, presented traditionally the major setback of artemisinin-based monotherapies. Although the introduction of artemisinin combination therapies (ACT) largely solved the problem, the ability of artemisinin to induce dormant...