An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection

An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection

Mycobacterium abscessus pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the need for improved preclinical drug testing. We present a simplif...

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Bibliographic Details
Main Authors: Sun, Yan, Zhang, Kaixi, Santos, May Delos, Pee, Carmen J. E., Yang, Yanmeng, Kang, Meiqi, Shin, Sung Jae, Chan-Park, Mary B., Pethe, Kevin
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Mouse model
Lung infection
Online Access:https://hdl.handle.net/10356/180529
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Institution: Nanyang Technological University
Language: English
Description
Summary:Mycobacterium abscessus pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the need for improved preclinical drug testing. We present a simplified immunosuppressed mouse model using only four injections of cyclophosphamide, which allows for sustained M. abscessus lung burden for up to 16 days. This model proved effective for antibiotic efficacy evaluation, as demonstrated with imipenem or amikacin.

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