Cryo-EM reveals transition states of the Acinetobacter baumannii F1-ATPase rotary subunits γ and ε, unveiling novel compound targets

Cryo-EM reveals transition states of the Acinetobacter baumannii F1-ATPase rotary subunits γ and ε, unveiling novel compound targets

Priority 1: critical WHO pathogen Acinetobacter baumannii depends on ATP synthesis and ATP:ADP homeostasis and its bifunctional F1FO-ATP synthase. While synthesizing ATP, it regulates ATP cleavage by its inhibitory ε subunit to prevent wasteful ATP consumption. We determined cryo-electron microscopy...

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Bibliographic Details
Main Authors: Le, Khoa Cong Minh, Wong, Chui Fann, Müller, Volker, Grüber, Gerhard
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2025
Subjects:
Medicine, Health and Life Sciences
ATP synthesis
Bioenergetics
Online Access:https://hdl.handle.net/10356/182447
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/182447

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